Factors Associated with the Extent of Clinical Attachment Loss in Periodontitis: A Multicenter Cross-Sectional Study

Fecha de publicación: 01/01/2023 Fecha Ahead of Print: 09/11/2023

Autores organización

Autores

Contreras A
Duque A
Giraldo A
Duarte S
Gutierrez SJ
Ardila CM

Grupos de investigación

Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

Investigador

Maria Consuelo Romero Sanchez
Unidad de Investigación Básica Oral UIBO

Investigador

Gloria Ines Lafaurie Villamil

Resumen

Periodontitis has significant public health implications, affecting individuals’ overall health, well-being, and quality of life. This study aimed to assess the risk factors associated with the extent of clinical attachment loss (CAL) in a population diagnosed with periodontitis. Six hundred and sixty-seven patients with different degrees of CAL (mild, n = 223; moderate, n = 256; and advanced, n = 188) were enrolled. Socio-demographics, lifestyle, microbiological profiles, specific immune response, obesity, and single-nucleotide polymorphism of the IL1 gene were determined. Unconditional logistic regression models were conducted to determine the factors associated with the extent of CAL. Aging, smoking, microbial factors, plaque index, and IgG2 antibodies against Aggregatibacter actinomycetemcomitans were associated with advanced CAL. IgG2 antibodies against A. actinomycetemcomitans (OR 1.50; CI 95% 1.23–1.81), plaque accumulation (OR 2.69; CI 95% 2.20–3.29), Porphyromonas gingivalis (OR 1.93; CI 95% 1.35–2.76), Tanerella forsythia (OR 1.88; CI 95%1.30–2.70), and current smoking (OR 1.94; CI 95% 1.31–2.87) were associated with advanced CAL. Gene IL polymorphisms, obesity, and stress were not associated with the extent of CAL. Aging, plaque accumulation, smoking, and having antibodies against A. actinomycetemcomitans were the most critical factors associated with advanced CAL. In contrast, obesity, stress, and gene polymorphisms were not associated with the extent of CAL. © 2023 by the authors.

Datos de la publicación

ISSN/ISSNe:: 1661-7827, 1660-4601
Tipo:: Article
Páginas:: -
DOI:: 10.3390/ijerph20227043
Enlace a otro recurso:: www.scopus.com

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Métricas

Filiaciones

Lafaurie GI:: Universidad. Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota, 11001, Colombia
Sabogal MA:: Universidad. Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota, 11001, Colombia
Contreras A:: Periodontal Medicine Group, Universidad del Valle, Cali, 760042, Colombia
Castillo DM:: Universidad. Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota, 11001, Colombia
Gualtero DF:: Universidad. Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota, 11001, Colombia
Avila J:: Universidad. Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota, 11001, Colombia
Trujillo TG:: Universidad. Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota, 11001, Colombia
Duque A:: Research Group in Basic Sciences and Clinical Dentistry, CES University, Medellin, 050021, Colombia
Giraldo A:: Research Group in Basic Sciences and Clinical Dentistry, CES University, Medellin, 050021, Colombia
Duarte S:: Dental Research Center-CIO, Pontificia Universidad Javeriana, Bogota, 110311, Colombia
Gutierrez SJ:: Periodontal Medicine Group, Universidad del Valle, Cali, 760042, Colombia
Ardila CM:: Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia UdeA, Medellin, 050010, Colombia

Keywords

Bacteroides; Cross-Sectional Studies; Humans; Immunoglobulin G; Obesity; Periodontitis; Quality of Life; immunoglobulin G1; immunoglobulin G2; interleukin 1; interleukin 1alpha; interleukin 1beta; immunoglobulin G; antibody; dental health; gene; immune response; lifestyle; obesity; polymorphism; public health; risk factor; smoking; adult; Aggregatibacter actinomycetemcomitans; aging; alcohol consumption; Article; bleeding on probing; blood cell count; blood sampling; body mass; clinical attachment level; controlled study; cross-sectional study; current smoker; enzyme linked immunosorbent assay; female; gene; gene frequency; gingival index; human; hydrocortisone blood level; IL1 gene; immune response; lifestyle; major clinical study; male; multicenter study; obesity; periodontal pocket depth; periodontitis; plaque index; polymerase chain reaction; Porphyromonas gingivalis; questionnaire; risk factor; single nucleotide polymorphism; smoking; Bacteroides; clinical trial; microbiology; per