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Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016)

Fecha de publicación: Fecha Ahead of Print:

Autores organización

Autores

  • Martínez JRW
  • Planet PJ
  • Spencer-Sandino M
  • Rivas L
  • Díaz L
  • Moustafa AM
  • Quesille-Villalobos A
  • Riquelme-Neira R
  • Alcalde-Rico M
  • Hanson B
  • Lam M
  • Calderon JF
  • Araos R
  • García P
  • Arias CA
  • Munita JM

Grupos de investigación

Resumen

The global dissemination of methicillin-resistant Staphylococcus aureus (MRSA) is associated with the emergence and establishment of clones in specific geographic areas. The Chilean-Cordobes clone (ChC) (ST5-SCCmecI) has been the predominant MRSA clone in Chile since its first description in 1998, despite the report of other emerging MRSA clones in recent years. Here, we characterize the evolutionary history of MRSA from 2000 to 2016 in a Chilean tertiary health care center using phylogenomic analyses. We sequenced 469 MRSA isolates collected between 2000 and 2016. We evaluated the temporal trends of the circulating clones and performed a phylogenomic reconstruction to characterize the clonal dynamics. We found a significant increase in the diversity and richness of sequence types (STs; Spearman r = 0.8748, P , 0.0001) with a Shannon diversity index increasing from 0.221 in the year 2000 to 1.33 in 2016, and an effective diversity (Hill number; q = 2) increasing from 1.12 to 2.71. The temporal trend analysis revealed that in the period 2000 to 2003 most of the isolates (94.2%; n = 98) belonged to the ChC clone. However, since then, the frequency of the ChC clone has decreased over time, accounting for 52% of the collection in the 2013 to 2016 period. This decline was accompanied by the rise of two emerging MRSA lineages, ST105-SCCmecII and ST72-SCCmecVI. In conclusion, the ChC clone remains the most frequent MRSA lineage, but this lineage is gradually being replaced by several emerging clones, the most important of which is clone ST105-SCCmecII. To the best of our knowledge, this is the largest study of MRSA clonal dynamics performed in South America. © 2023 Martínez et al.

Datos de la publicación

ISSN/ISSNe:
2165-0497, 2165-0497

Microbiology Spectrum  American Society for Microbiology

Tipo:
Article
Páginas:
-
PubMed:
37338398
Enlace a otro recurso:
www.scopus.com

Citas Recibidas en Web of Science: 1

Citas Recibidas en Scopus: 6

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Keywords

  • Anti-Bacterial Agents; Chile; Humans; Methicillin-Resistant Staphylococcus aureus; Phylogeny; Staphylococcal Infections; Tertiary Care Centers; antiinfective agent; article; bacterium isolate; clonal variation; genomics; major clinical study; methicillin resistance; methicillin resistant Staphylococcus aureus; nonhuman; Shannon index; South America; Staphylococcus aureus; tertiary care center; Chile; genetics; human; phylogeny; Staphylococcus infection

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