Portal de investigación
Analysis of Ana/Dfs70 Pattern in a Large Cohort of Autoimmune/Autoinflammatory Diseases Compared with First Degree Relatives and Healthy Controls Evaluated from Colombia
Fecha de publicación:
Autores organización
Autores
- Romero-Alvarez V.
- Vargas-Martin A.
- Castro L.
- Amador J.
- Marín-Acevedo D.
- Acevedo-Godoy M.
- Rincón-Riaño D.
- Bello-Gualtero J.M.
Grupos de investigación
Resumen
Background: The presence of Antinuclear antibodies/Dense Fine Speckled 70 (ANA/DFS70) has been proposed as a negative biomarker in the process of exclusion of systemic autoimmune/autoinflammatory rheumatic diseases (SARD). The purpose was to evaluate and characterize ANA/DFS70 patients in a large Colombian population with SARD; rheumatoid arthritis (RA), Psoriasis (PsO), Undifferentiated connective tissue disease (UCTD), first-degree relatives of (FDR), and healthy controls (HC). Methods: ANA determination was performed using indirect immunofluorescence. Samples with positive dense fine granular staining in the nucleoplasm of the interphase cell (AC2) fluorescence were confirmed with CytoBead/ANA and ANA/modified (Knocked out for the PSPI1 gen). Results: 530 mestizo Colombian participants were included. ANA/DFS70 antibody positivity in the whole group was 2.3%, and 0.8% in SARD; no RA patients were positive. ANA/DFS70 positives in UCTD were three women; the average time of evolution of the disease was 9.4 years. The most frequent clinical findings were arthralgias, non-erosive arthritis, and Raynaud’s phenomenon. The PsO positive was a woman with C-reactive protein (CRP) positivity and a negative erythrocyte sedimentation rate (ESR) without any other positive autoantibody or extracutaneous manifestation. FDR and HC positives were 7/8 women. All were negative for other autoantibodies. Conclusions: ANA/DFS70 autoantibodies were present in Colombian patients with SARD at a shallow frequency, they were more prevalent in healthy individuals. © 2022 by the authors.
Datos de la publicación
- ISSN/ISSNe:
- 2075-4418, 2075-4418
- Tipo:
- Article
- Páginas:
- -
- Enlace a otro recurso:
- www.scopus.com
Diagnostics Multidisciplinary Digital Publishing Institute (MDPI)
Citas Recibidas en Web of Science: 1
Citas Recibidas en Scopus: 3
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Filiaciones
Keywords
- antinuclear antibody; autoantibody; beta2 glycoprotein 1 antibody; C reactive protein; cardiolipin antibody; cyclic citrullinated peptide antibody; dense fine speckled 70 antibody; double stranded DNA antibody; rheumatoid factor; unclassified drug; adult; arthralgia; arthritis; Article; autoimmune disease; autoinflammatory disease; cohort analysis; Colombia; Colombian; controlled study; economic incentive; erythrocyte sedimentation rate; female; first-degree relative; human; immunofluorescence; interphase; major clinical study; male; psoriasis; Raynaud phenomenon; rheumatoid arthritis; undifferentiated connective tissue disease
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Citar la publicación
Romero C,Calixto O-J,Romero V,Vargas A,Castro L,Amador J,Marín D,Acevedo M,Rincón D,Bello JM. Analysis of Ana/Dfs70 Pattern in a Large Cohort of Autoimmune/Autoinflammatory Diseases Compared with First Degree Relatives and Healthy Controls Evaluated from Colombia. Diagnostics (Basel). 2022. 12. (9):2181. IF:3,600. (2).