Oral manifestations associated with inflammatory bowel disease and early endoscopic findings in patients with spondyloarthritis

Autores organización

• Maria Rosa Buenahora Tobar

  Autor

• Viviana Viviana Parra Izquierdo

  Autor

• Leidy Lorena Chila Moreno

  Autor

• 

  Manuel Alejandro Ramos Casallas

  Autor

• 

  Juliette De Avila Quiroga

  Autor

• Wilson Armando Bautista Molano

  Autor

• Maria Consuelo Romero Sanchez

  Autor

Autores

• Alvarado-Julio A.
• Chumacero-Palma K.
• Monsalve M.
• Torres A.M.
• Flórez-Sarmiento C.
• Bello-Gualtero J.M.
• Jaimes D.
• Beltrán-Ostos A.
• Chalem-Choueka P.
• Pacheco-Tena C.

Grupos de investigación

• Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

  Investigador

  Maria Consuelo Romero Sanchez

• Unidad de Epidemiología Clínica Oral UNIECLO

  Investigador

  Maria Rosa Buenahora Tobar

Resumen

Background and aims: Spondyloarthritis (SpA) is a group of autoinflammatory disorders, of which the primary extra-articular manifestation is inflammatory bowel disease (IBD). The oral cavity being a part of gastrointestinal tract, is significantly compromised in IBD, and in many cases, it is the first site of clinical manifestations of IBD. This study aimed to identify changes in the oral mucosa associated with the onset of IBD and their association with endoscopic/histological findings. Materials and methods: The study assessed 80 patients with SpA and 52 healthy controls. Oral, rheumatological, and gastroenterological assessments were performed. The ileocolonoscopy was performed via digital magnification chromoendoscopy. The statistical analysis consisted of Chi-square, Fisher's exact, and multiple correspondence discriminant analysis tests. Results: From the disease cohort, 63.0% patients showed oral lesions (p = 0.050). These manifestations ranged from gingivitis (55.0%, p = 0.001), aphthous stomatitis (3.8%, p = 0.091), angular cheilitis (2.6%, p = 0.200), and perioral erythema with scaling (1.3%, p = 0.300). All patients who presented with alterations in colonic mucosa also had oral lesions associated with IBD (p = 0.039), specifically gingivitis/aphthous stomatitis (p = 0.029). Conclusion: The patients with SpA without IBD present significant oral signs and symptoms. Gingivitis seems to be the most relevant because of its associations with early endoscopic and histological findings. Clinical relevance: An integral approach to the diagnostic tests that includes evaluations of oral, rheumatological and gastroenterological tissues may favor timely attention and improve patients’ quality of life. © 2022, The Author(s).

Keywords

• Chronic Disease; Gingivitis; Humans; Inflammatory Bowel Diseases; Oral Ulcer; Quality of Life; Rheumatic Diseases; Spondylarthritis; Stomatitis, Aphthous; aphthous stomatitis; chronic disease; complication; gingivitis; human; inflammatory bowel disease; mouth ulcer; quality of life; rheumatic disease; spondylarthritis