High Levels of Leptin and Adipsin Are Associated with Clinical Activity in Early Rheumatoid Arthritis Patients with Overweight and Periodontal Infection

Autores organización

• Maria Consuelo Romero Sanchez

  Autor

• 

  Juliette De Avila Quiroga

  Autor

• 

  Manuel Alejandro Ramos Casallas

  Autor

• Leidy Lorena Chila Moreno

  Autor

• 

  Nathaly Andrea Delgadillo Salgado

  Autor

• Wilson Armando Bautista Molano

  Autor

Autores

• Chalem-Choueka P
• Pacheco-Tena C
• Bello-Gualtero JM

Grupos de investigación

• Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

  Investigador

  Maria Consuelo Romero Sanchez

• Unidad de Investigación Básica Oral UIBO

  

  Investigador

  Gloria Ines Lafaurie Villamil

Resumen

Adipokines are associated with the pathogenesis of rheumatoid arthritis (RA) and are potential biomarkers of disease activity, periodontitis, and obesity. The aim of this was to establish the association between adipokine profile, RA disease activity, body mass index, and periodontal infection. This study evaluated 51 patients with early-RA and 51 controls including serum rheumatological markers, adipokine levels, detection of Porphyromonas gingivalis and serum anti-Porphyromonas gingivalis antibodies, clinical and periodontal measurements. Statistical analyses were run with SPSS® V26, with a logistic regression model to confirm associations. The results show high levels of leptin were more frequent in patients (p = 0.001) who simultaneously showed a higher frequency of Porphyromonas gingivalis (p = 0.004). Patients with concomitant presence of Porphyromonas gingivalis, high clinical activity score, and overweight were correlated with high levels of leptin (OR, 7.20; 95% CI, 2.68–19.33; p = 0.0001) and adipsin (OR, 2.69; 95% CI, 1.00–7.28; p = 0.005). The conclusion is that high levels of leptin and adipsin are associated with greater clinical activity in early-RA patients with overweight and periodontal infection, whereby overweight and Porphyromonas gingivalis may enhance RA activity. This may represent a pathological mechanism between these conditions, where adipokines seem to have a key role. © 2023 by the authors.

Keywords

• adipocytokine; complement factor D; leptin; adult; Article; body mass; clinical evaluation; controlled study; disease association; female; gene expression; gene frequency; human; human tissue; major clinical study; male; nonhuman; obesity; periodontitis; periodontium; Porphyromonas gingivalis; protein blood level; protein expression; rheumatoid arthritis; tooth infection