Worldwide Dissemination of blaKPC Gene by Novel Mobilization Platforms in Pseudomonas aeruginosa: A Systematic Review

Fecha de publicación: 01/01/2023 Fecha Ahead of Print: 28/03/2023

Autores organización

Autores

Forero-Hurtado D
Ruiz-Castellanos JS
Márquez-Ortiz RA
Vanegas N

Grupos de investigación

Laboratorio de Genética Molecular Bacteriana LGMB

Investigador

Javier Antonio Escobar Perez
Unidad de Investigación Básica Oral UIBO

Investigador

Gloria Ines Lafaurie Villamil

Resumen

The dissemination of blaKPC-harboring Pseudomonas aeruginosa (KPC-Pa) is considered a serious public health problem. This study provides an overview of the epidemiology of these isolates to try to elucidate novel mobilization platforms that could contribute to their worldwide spread. A systematic review in PubMed and EMBASE was performed to find articles published up to June 2022. In addition, a search algorithm using NCBI databases was developed to identify sequences that contain possible mobilization platforms. After that, the sequences were filtered and pair-aligned to describe the blaKPC genetic environment. We found 691 KPC-Pa isolates belonging to 41 different sequence types and recovered from 14 countries. Although the blaKPC gene is still mobilized by the transposon Tn4401, the non-Tn4401 elements (NTEKPC) were the most frequent. Our analysis allowed us to identify 25 different NTEKPC, mainly belonging to the NTEKPC-I, and a new type (proposed as IVa) was also observed. This is the first systematic review that consolidates information about the behavior of the blaKPC acquisition in P. aeruginosa and the genetic platforms implied in its successful worldwide spread. Our results show high NTEKPC prevalence in P. aeruginosa and an accelerated dynamic of unrelated clones. All information collected in this review was used to build an interactive online map. © 2023 by the authors.

Datos de la publicación

ISSN/ISSNe:: 2079-6382, 2079-6382
Tipo:: Review
Páginas:: -
DOI:: 10.3390/antibiotics12040658
Enlace a otro recurso:: www.scopus.com

Documentos

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Métricas

Filiaciones

Forero-Hurtado D:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia
Corredor-Rozo ZL:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia
Ruiz-Castellanos JS:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia
Márquez-Ortiz RA:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia
Abril D:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia
Vanegas N:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia

The i3 Institute, Faculty of Science, University of Technology, Sydney, 2007, NSW, Australia
Lafaurie GI:: Universidad. Unit of Basic Oral Investigations-UIBO, Universidad El Bosque, Bogota, 110121, Colombia
Chambrone L:: Universidad. Unit of Basic Oral Investigations-UIBO, Universidad El Bosque, Bogota, 110121, Colombia

Evidence-Based Hub, Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz-Cooperativa de Ensino Superior, Almada, Caparica, 2829-511, Portugal

Department of Periodontics, School of Dental Medicine, The University of Pennsylvania, Philadelphia, 19104, PA, United States
Escobar-Pérez J:: Universidad. Bacterial Molecular Genetics Laboratory-LGMB, Universidad El Bosque, Ak. 9 #131a-02, Bogota, 110121, Colombia

Keywords

carbapenemase; transposase; bacterium isolate; carbapenem resistance; computer model; Embase; Klebsiella pneumoniae; Medline; mobilization; nonhuman; open reading frame; Pseudomonas aeruginosa; public health; Review; systematic review; transposon