Implementation of screening criteria for inflammatory bowel disease in patients with spondyloarthritis and its association with disease and endoscopic activity

Autores organización

• Viviana Viviana Parra Izquierdo

  Autor

• 

  Juliette De Avila Quiroga

  Autor

• 

  Manuel Alejandro Ramos Casallas

  Autor

• Leidy Lorena Chila Moreno

  Autor

• Wilson Armando Bautista Molano

  Autor

• Maria Consuelo Romero Sanchez

  Autor

Autores

• Gutiérrez-Sánchez J
• Flórez-Sarmiento C
• Jaimes DA
• Bello-Gualtero JM
• Pacheco-Tena C
• Beltrán-Ostos A
• Chalem-Choueka P

Grupos de investigación

• Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

  Investigador

  Maria Consuelo Romero Sanchez

Resumen

There is little literature on the implementation of screening criteria for inflammatory bowel disease (IBD) in patients with spondyloarthritis (SpA). This study aimed to apply IBD screening criteria in a group of patients with SpA without IBD diagnosis and correlate them to endoscopic findings and disease activity. A total of 82 patients with SpA were included. The IBD screening test and ileocolonoscopy with digital chromoendoscopy with magnification and histological analysis were performed. The data were analysed with Chi-square test/Fisher’s exact test and multiple correspondence analysis. The major screening criteria found in 48.7% of the patients were associated with a history of infection (p = 0.037). Rectal bleeding was associated with the diagnosis of ankylosing spondylitis, acute inflammation, enthesitis and tissue architecture alteration in the ileum (p < 0.050). Diarrhoea was associated with a higher disease activity score (p = 0.02). Minor screening criteria were associated with painful inflammatory joint (p = 0.05), high disease activity score (p = 0.001) and high calprotectin levels (p = 0.050). Abdominal pain (36.9%) was associated with axial/peripheral compromise (p = 0.017), inflammatory back pain (p = 0.01), enthesitis (p = 0.021), higher disease activity score (p = 0.023) and acute ileum inflammation (p = 0.046). Diarrhoea of 4 weeks and abdominal pain were the most prevalent major and minor screening criteria, respectively, being related to early manifestations of inflammatory bowel compromise and higher disease activity score. This screening test grants a chance of opportune referral of SpA patients from rheumatology to gastroenterology. © 2022, The Author(s).

© 2022. The Author(s).

Keywords

• Abdominal Pain; Diarrhea; Humans; Inflammation; Inflammatory Bowel Diseases; Spondylarthritis; Spondylitis, Ankylosing; calgranulin; abdominal pain; ankylosing spondylitis; arthralgia; Article; backache; Bath ankylosing spondylitis disease activity index; Bath ankylosing spondylitis functional index; chromoendoscopy; Colombian; correlation coefficient; cross-sectional study; diarrhea; digestive system disease assessment; disease activity; disease activity score; disease association; enthesitis; female; histopathology; human; ileitis; ileocolonoscopy; ileum tissue; implementation science; infection; inflammation; inflammatory bowel disease; Inflammatory Bowel Disease screening criteria; inflammatory pain; intermethod comparison; magnifying endoscopy; major clinical study; male; medical history; prevalence; rectum hemorrhage; spondylarthritis; white light endoscopy; ankylosing spondylitis; complication; inflammatory bowel disease; spondylarthritis