Portal de investigación
Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions
Fecha de publicación:
Fecha Ahead of Print:
Autores organización
Autores
- Hernández-Gómez C
- Appel TM
- Escandón K
- Reyes S
- Salcedo S
- Matta L
- Martínez E
- Cobo S
- Mora L
- Marín A
- Correa A
- Rodríguez-Baño J
Grupos de investigación
Resumen
Background: Antimicrobial stewardship programs (ASPs) have become a fundamental pillar in optimizing antimicrobial usage, improving patient care, and reducing antimicrobial resistance (AMR). Herein we evaluated the impact of an ASP on antimicrobial consumption and AMR in Colombia. Methods: We designed a retrospective observational study and measured trends in antibiotic consumption and AMR before and after the implementation of an ASP using interrupted time series analysis over a 4-year period (24 months before and 24 months after ASP implementation). Results: ASPs were implemented according to the available resources in each of the institutions. Before ASP implementation, there was a trend toward an increase in the antibiotic consumption of all measured antimicrobials selected. Afterward, an overall decrease in antibiotic consumption was observed. The use of ertapenem and meropenem decreased in hospital wards, while a decrease in the use of ceftriaxone, cefepime, piperacillin/tazobactam, meropenem, and vancomycin was observed in intensive care units. After ASP implementation, the trend toward an increase of oxacillin-resistant Staphylococcus aureus, ceftriaxone-resistant Escherichia coli, and meropenem-resistant Pseudomonas aeruginosa was reversed. Conclusions: In our study, we showed that ASPs are a key strategy in tackling the emerging threat of AMR and have a positive impact on antibiotic consumption and resistance. © 2022, The Author(s).
© 2022. The Author(s).
Datos de la publicación
- ISSN/ISSNe:
- 1471-2334, 1471-2334
- Tipo:
- Article
- Páginas:
- 420-420
- Enlace a otro recurso:
- www.scopus.com
Bmc Infectious Diseases BioMed Central Ltd
Citas Recibidas en Web of Science: 9
Citas Recibidas en Scopus: 15
Documentos
- No hay documentos
Filiaciones
Keywords
- Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Stewardship; Ceftriaxone; Colombia; Delivery of Health Care; Drug Resistance, Bacterial; Humans; Meropenem; Methicillin-Resistant Staphylococcus aureus; cefepime; ceftriaxone; ertapenem; meropenem; piperacillin plus tazobactam; vancomycin; antiinfective agent; meropenem; antibiotic resistance; antibiotic therapy; antimicrobial stewardship; Article; Colombia; Colombian; drug use; Escherichia coli; human; intensive care unit; nonhuman; observational study; oxacillin-resistant Staphylococcus aureus; Pseudomonas aeruginosa; retrospective study; ward; antibiotic resistance; health care delivery; methicillin resistant Staphylococcus aureus
Proyectos asociados
Colonización como factor de riesgo asociado a la infección por Enterobacterales productores de carbapenemasas (CPE) en pacientes hospitalizados en unidades de cuidados intensivos (UCI) en dos instituciones de salud en Colombia
Investigador Principal: MARIA VIRGINIA VILLEGAS BOTERO
PCI-2022-11023 . 2022
Creating a Latin America network for clinical training and support of pharmacists and hospital financial decision makers involved in ASPs
Investigador Principal: MARIA VIRGINIA VILLEGAS BOTERO
UEB-2020-585 . 2020
Caracterización Molecular de Aislamientos Resistentes a Ceftazidime Avibactam en Enterobacterales y Pseudomonas aeruginosa recolectados en cinco Países de América Latina. Molecular mechanisms leading to ceftazidime-avibactam resistance in Enterobacterales and Pseudomonas aeruginosa collected from five Latin American countries
Investigador Principal: MARIA VIRGINIA VILLEGAS BOTERO
UEB-2020-586 . 2020
Haciendo frente a la multidrogo resistencia en Klebsiella pneumoniae: dinámica y evolución de plásmidos portadores de carbapenemasa en un país endémico para KPC
Investigador Principal: MARIA VIRGINIA VILLEGAS BOTERO
2022
Estudio comparativo in vitro de Ceftriaxona-Sulbactam-EDTA y antibióticos comparadores contra bacilos Gram negativos productores de β-lactamasas
Investigador Principal: MARIA VIRGINIA VILLEGAS BOTERO
UEB-ID-2021-638 . 2022
Citar la publicación
Pallares C,Hernández C,Appel TM,Escandón K,Reyes S,Salcedo S,Matta L,Martínez E,Cobo S,Mora L,Marín A,Correa A,De La Cadena E,Rodríguez J,Villegas MV. Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions. BMC Infect Dis. 2022. 22. (1):p. 420-420. IF:3,700. (3).