Endothelial Dysfunction, HMGB1, and Dengue: An Enigma to Solve

Autores organización

• Maria Angelica Calderon Pelaez

  Autor

• Carolina Coronel Ruiz

  Autor

• 

  Jaime Eduardo Castellanos Parra

  Autor

• 

  Myriam Lucia Velandia Romero

  Autor

Grupos de investigación

• Grupo de Virología

  

  Investigador

  Jaime Eduardo Castellanos Parra

Resumen

Dengue is a viral infection caused by dengue virus (DENV), which has a significant impact on public health worldwide. Although most infections are asymptomatic, a series of severe clinical manifestations such as hemorrhage and plasma leakage can occur during the severe presentation of the disease. This suggests that the virus or host immune response may affect the protective function of endothelial barriers, ultimately being considered the most relevant event in severe and fatal dengue pathogenesis. The mechanisms that induce these alterations are diverse. It has been suggested that the high mobility group box 1 protein (HMGB1) may be involved in endothelial dysfunction. This non-histone nuclear protein has different immunomodulatory activities and belongs to the alarmin group. High concentrations of HMGB1 have been detected in patients with several infectious diseases, including dengue, and it could be considered as a biomarker for the early diagnosis of dengue and a predictor of complications of the disease. This review summarizes the main features of dengue infection and describes the known causes associated with endothelial dysfunction, highlighting the involvement and possible relationship between HMGB1 and DENV. © 2022 by the authors.

Keywords

• Dengue; Dengue Virus; Hemorrhage; HMGB1 Protein; Humans; Vascular Diseases; alarmin; alpha interferon; anaphylatoxin; C reactive protein; cholesterol; complement; complement component C3a; complement component C5a; cytokine; fatty acid binding protein; gamma interferon; glucose; hepatitis B virus X protein; high mobility group B1 protein; immunoglobulin enhancer binding protein; vascular cell adhesion molecule 1; high mobility group B1 protein; acute on chronic liver failure; antiretroviral therapy; bile duct atresia; blood clotting disorder; blood vessel permeability; Child Pugh score; Coxsackievirus B3; dengue; disorders of higher cerebral function; endothelial dysfunction; endothelium lesion; genetic transcription; Hepatitis B virus; Hepatitis C virus; Herpes simplex virus 2; human; Human immunodeficiency virus; Human respiratory syncytial virus; Human rotavirus; Human T-lymphotropic virus 1; immune deficiency; immune response; immunotherapy; inflammatory bowel disease; Influenza A