Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses;

Autores organización

• Ximena Carolina Romero Infante

  Autor

Autores

• Uriel M
• Gutiérrez A
• Hernández MF
• Hernández AF
• Jiménez LC
• Malagón-Rojas JN
• Rincón Franco S

Grupos de investigación

• Grupo de Investigación Medicina Materno Fetal y Ginecología - El Bosque MMFG-EB

  Investigador

  Ximena Carolina Romero Infante

Resumen

Objective â This study aims to describe the behavior of chromosomopathy screenings in euploid fetuses. Methods â This is a prospective descriptive study with 566 patients at 11 to 14 weeks of gestation. The associations between ultrasound scans and serological variables were studied. For the quantitative variables we used the Spearman test; for the qualitative with quantitative variables the of Mann-Whitney U-Test; and for qualitative variables, the X 2test was applied. Significance was set at p = 0.05. Results â We have found that gestational age has correlation with ductus venosus, nuchal translucency, free fraction of ß subunit of human chorionic gonadotropin, pregnancy-Associated plasma protein-A and placental growth factor; there is also a correlation between history of miscarriages and nasal bone. Furthermore, we correlated body mass index with nuchal translucency, free fraction of ß subunit of human chorionic gonadotropin, and pregnancy-Associated plasma protein-A. Maternal age was associated with free fraction of ß subunit of human chorionic gonadotropin and pregnancy-Associated plasma protein-A. Conclusion â Our study demonstrates for the first time the behavior of the biochemical and ultrasonographic markers of chromosomopathy screenings during the first trimester in euploid fetuses in Colombia. Our information is consistent with international reference values. Moreover, we have shown the correlation of different variables with maternal characteristics to determine the variables that could help with development of a screening process during the first trimester with high detection rates. © 2022 Georg Thieme Verlag. All rights reserved.

Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Keywords

• Biomarkers; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Chromosome Disorders; Down Syndrome; Female; Fetus; Genetic Markers; Humans; Maternal Age; Nuchal Translucency Measurement; Placenta Growth Factor; Pregnancy; Pregnancy Trimester, First; Pregnancy-Associated Plasma Protein-A; Prenatal Diagnosis; biological marker; chorionic gonadotropin; chorionic gonadotropin beta subunit; placental growth factor; pregnancy associated plasma protein A; chromosome disorder; Down syndrome; female; fetus; first trimester pregnancy; genetic marker; human; maternal age; metabolism; nuchal translucency measurement; pregnancy; prenatal diagnosis