Chemopreventive and Anti-tumor Potential of Natural Products in Oral Cancer

Fecha de publicación: 01/01/2022 Fecha Ahead of Print: 01/05/2021

Autores organización

Autores

Olivares-Niño G

Grupos de investigación

Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

Investigador

Maria Consuelo Romero Sanchez
Unidad de Investigación Básica Oral UIBO

Investigador

Gloria Ines Lafaurie Villamil

Resumen

Oral cancer (OC) is a multifactorial disease caused by isolated or combined risk factors related to tobacco, alcohol consumption, and human papillomavirus infection. It is an aggressive pathology with a low five-year survival rate after surgery, chemotherapy, and/or radiotherapy, frequently associated with severe side effects. Drugs with the highest anti-tumor effect are obtained from natural products with diverse biological and molecular activities and potential chemopreventive and anticancer properties. This review summarizes the natural products reported to have the chemopreventive and anti-tumor potential for OC treatment, showing that several of these compounds are promising candidates as chemopreventive agents, and those with the highest anti-tumor potential induce apoptosis and inhibit proliferation and metastasis-related processes. For this reason, natural products have the potential to be important preventive and therapeutic options for OC in the future. © 2021 Taylor & Francis Group, LLC.

Datos de la publicación

ISSN/ISSNe:: 0163-5581, 1532-7914
Tipo:: Review
Páginas:: 779-795
DOI:: 10.1080/01635581.2021.1931698
Enlace a otro recurso:: www.scopus.com

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Métricas

Filiaciones

Cardona-Mendoza A:: Universidad. Grupo de Inmunología Celular y Molecular Universidad El Bosque-INMUBO, Universidad El Bosque, Bogotá, Colombia

Universidad. School of Dentistry, Universidad El Bosque, Bogotá, Colombia
Olivares-Niño G:: Universidad. School of Dentistry, Universidad El Bosque, Bogotá, Colombia
Díaz-Báez D:: Universidad. Unidad de Investigación Básica Oral-UIBO, Universidad El Bosque, Bogotá, Colombia

Universidad. School of Dentistry, Universidad El Bosque, Bogotá, Colombia
Lafaurie GI:: Universidad. Unidad de Investigación Básica Oral-UIBO, Universidad El Bosque, Bogotá, Colombia

Universidad. School of Dentistry, Universidad El Bosque, Bogotá, Colombia
Perdomo SJ:: Universidad. Grupo de Inmunología Celular y Molecular Universidad El Bosque-INMUBO, Universidad El Bosque, Bogotá, Colombia

Universidad. School of Dentistry, Universidad El Bosque, Bogotá, Colombia

Keywords

Anticarcinogenic Agents; Apoptosis; Biological Products; Humans; Mouth Neoplasms; natural product; antineoplastic agent; biological product; antineoplastic activity; antiproliferative activity; apoptosis; cancer cell; cell cycle arrest; chemoprophylaxis; human; metastasis inhibition; mouth cancer; nonhuman; proapoptotic activity; Review; tumor invasion; mouth tumor