Portal de investigación
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics
Fecha de publicación:
Autores organización
Autores
- Ruiz-Patiño A.
- Rodríguez J.
- Ávila J.
- Archila P.
- Carranza H.
- Vargas C.
- Otero J.
- Arrieta O.
- Zatarain-Barrón L.
- Sotelo C.
- Ordoñez C.
- García-Robledo J.E.
- Bermúdez M.
- Gámez T.
- Mayorga D.
- Corrales L.
- Martín C.
- Recondo G.
- Mas L.
- Samtani S.
- Ricaurte L.
- Malapelle U.
- Russo A.
- Barrón F.
- Santoyo N.
- Rolfo C.
- Rosell R.
Grupos de investigación
Resumen
Background: The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing in relevance due to the development and effectiveness of new treatment medications. Studies around different populations indicate that regional variability between ethnic groups and ancestries could play an essential role in developing this molecular alteration within lung cancer. Methods: In a prospective and retrospective cohort study on samples from lung adenocarcinoma from 1000 patients from different administrative regions in Colombia were tested for the KRAS p.G12C mutation. An analysis of STR populations markers was conducted to identify substructure contributions to mutation prevalence. Results: Included were 979 patients with a national mean frequency for the KRAS exon 2 p.G12C mutation of 7.97% (95%CI 6.27–9.66%). Variation between regions was also identified with Antioquia reaching a positivity value of 12.7% (95%CI 9.1–16.3%) in contrast to other regions such as Bogota DC (Capital region) with 5.4% (2.7–8.2%) and Bolivar with 2.4% (95%CI 0–7.2%) (p-value = 0.00262). Furthermore, Short tandem repeat population substructures were found for eight markers that strongly yielded association with KRAS exon 2 p.G12C frequency reaching an adjusted R2 of 0.945 and a p-value of < 0.0001. Conclusions: Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, this type of mutation prevalence follows a population substructure pattern that can be easily determined by population and ancestral markers such as STR. © 2021
Datos de la publicación
- ISSN/ISSNe:
- 1936-5233,
- Tipo:
- Article
- Páginas:
- -
- Enlace a otro recurso:
- www.scopus.com
Translational Oncology Neoplasia Press, Inc.
Citas Recibidas en Web of Science: 9
Citas Recibidas en Scopus: 12
Documentos
- No hay documentos
Filiaciones
Keywords
- circulating tumor DNA; epidermal growth factor receptor; genomic DNA; K ras protein; paraffin; protein kinase B; Article; bioinformatics; blood sampling; cancer grading; cancer tissue; capillary electrophoresis; cohort analysis; controlled study; diagnostic test accuracy study; DNA extraction; droplet digital polymerase chain reaction; fluorometry; gene frequency; gene mutation; genetic variability; high throughput sequencing; histology; human; human tissue; lung adenocarcinoma; lung cancer; major clinical study; non small cell lung cancer; paraffin embedding; plasma; predictive value; prevalence; retrospective study; Sanger sequencing; sensitivity and specificity; spectrophotometry
Financiación
Proyectos asociados
EFECTO DEL EXTRACTO DE Trametes versicolor SOBRE EL FENOTIPO Y LA FUNCIÓN DE CÉLULAS DENDRÍTICAS HUMANAS CONDICIONADAS CON MEDIOS DE CÉLULAS DE CARCINOMA ORAL
Investigador Principal: ANDRES FELIPE CARDONA MENDOZA
PCI-2019-10805 . 2020
Citar la publicación
Ruiz A,Rodríguez J,Cardona AF,Ávila J,Archila P,Carranza H,Vargas C,Otero J,Arrieta O,Zatarain L,Sotelo C,Ordoñez C,García JE,Rojas L,Bermúdez M,Gámez T,Mayorga D,Corrales L,Martín C,Recondo G,Mas L,Samtani S,Ricaurte L,Malapelle U,Russo A,Barrón F,Santoyo N,Rolfo C,Rosell R. p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics. Transl Oncol. 2022. 15. (1):101276. IF:5,000. (2).