Portal de investigación
PD-L1 expression complements CALGB prognostic scoring system in malignant pleural mesothelioma
Fecha de publicación:
Fecha Ahead of Print:
Autores organización
Autores
- Avilés-Salas A
- Cabrera-Miranda L
- Hernández-Pedro N
- Vargas-Lías DS
- Samtani S
- Muñoz-Montaño W
- Motola-Kuba D
- Corrales-Rodríguez L
- Martín C
- Palomares-Palomares CB
- Arrieta O
Grupos de investigación
Resumen
Background: Programmed death ligand-1 (PD-L1) expression is a predictive biomarker in patients with lung cancer, but its role in malignant pleural mesothelioma (MPM) remains unclear. Evidence suggests that higher PD-L1 expression is correlated with worse survival. CALGB is the main scoring system used to predict the benefit of chemotherapy treatment. This study aimed to determine the prognostic value of PD-L1 expression and its addition to CALGB scoring system in patients with MPM. Methods: In this retrospective analysis, we evaluated samples with confirmed locally advanced or metastatic MPM. PD-L1 Tumor Proportional Score (TPS) was determined by immunohistochemistry at diagnosis. Results: 73 patients were included in this study. A cutoff value of 15 was set for a high or low PD-L1 TPS. In total, 71.2% (n=52) and 28.8% (n=21) of individuals harbored low or high PD-L1 expression, respectively. PD-L1High was associated with worse median progression-free Survival (mPFS) [4.9 vs. 10.8 months; HR 2.724, 95% CI (1.44-5.14); p = 0.002] and Overall Survival (OS) [6.0 vs. 20.9 months; HR 6.87, 95% CI (3.4-8.7); p<0.001] compared to patients with PD-L1Low. Multivariate analysis confirmed that PD-L1 expression was an independent factor for PFS and OS in patients with MPM and CALGB score of 5-6. Conclusion: PD-L1 addition to CALGB scale improves its prognostic estimation of MPM survival and should be considered in future research. Copyright © 2023 Avilés-Salas, Cabrera-Miranda, Hernández-Pedro, Vargas-Lías, Samtani, Muñoz-Montaño, Motola-Kuba, Corrales-Rodríguez, Martín, Cardona, Palomares-Palomares and Arrieta.
Copyright © 2023 Avilés-Salas, Cabrera-Miranda, Hernández-Pedro, Vargas-Lías, Samtani, Muñoz-Montaño, Motola-Kuba, Corrales-Rodríguez, Martín, Cardona, Palomares-Palomares and Arrieta.
Datos de la publicación
- ISSN/ISSNe:
- 2234-943X, 2234-943X
- Tipo:
- Article
- Páginas:
- 1269029-1269029
- Enlace a otro recurso:
- www.scopus.com
Frontiers In Oncology Frontiers Media S.A.
Citas Recibidas en Scopus: 2
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- No hay documentos
Filiaciones
Keywords
- programmed death 1 ligand 1; adult; aged; Article; cancer staging; cancer surgery; chemoradiotherapy; ECOG Performance Status; female; gene expression; histopathology; human; human tissue; immunohistochemistry; long term care; lymph node metastasis; major clinical study; male; palliative therapy; pleura mesothelioma; pleurectomy; pneumonectomy; prognosis; protein expression; retrospective study; scoring system
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Investigador Principal: CARLOS ALBERTO PUENTES MORALES
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Citar la publicación
Avilés A,Cabrera L,Hernández N,Vargas DS,Samtani S,Muñoz W,Motola D,Corrales L,Martín C,Cardona AF,Palomares CB,Arrieta O. PD-L1 expression complements CALGB prognostic scoring system in malignant pleural mesothelioma. Front Oncol. 2023. 13. p. 1269029-1269029. IF:3,500. (2).