Predictors of survival after head and neck squamous cell carcinoma in South America: The interchange study

Fecha de publicación: 01/01/2020

Autores organización

Sandra Janneth Perdomo Lara

Autor

Autores

Abrahão R.
Pinto L.F.R.
de Carvalho F.N.
Dias F.L.
de Podestá J.R.V.
von Zeidler S.V.
de Abreu P.M.
Vilensky M.
Giglio R.E.
Oliveira J.C.
Mineiro M.S.
Kowalski L.P.
Ikeda M.K.
Cuello M.
Munyo A.
Rodríguez-Urrego P.A.
Hakim J.A.
Suarez-Zamora D.A.
Cayol F.
Figari M.F.
Oliver J.
Gaborieau V.
Keogh R.H.
Brennan P.
Curado M.P.

Grupos de investigación

Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

Investigador

Maria Consuelo Romero Sanchez

Resumen

PURPOSE Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS Sociodemographic and lifestyle information was obtained from standardized interviews, and clinicopathologic data were extracted from medical records and pathologic reports. The Kaplan-Meier method and Cox regression were used for statistical analyses. RESULTS Of 1,463 patients, 378 had a larynx cancer (LC), 78 hypopharynx cancer (HC), 599 oral cavity cancer (OC), and 408 oropharynx cancer (OPC). Most patients (55.5%) were diagnosed with stage IV disease, ranging from 47.6% for LC to 70.8% for OPC. Three-year survival rates were 56.0% for LC, 54.7% for OC, 48.0% for OPC, and 37.8% for HC. In multivariable models, patients with stage IV disease had approximately 7.6 (LC/HC), 11.7 (OC), and 3.5 (OPC) times higher mortality than patients with stage I disease. Current and former drinkers with LC or HC had approximately 2 times higher mortality than never-drinkers. In addition, older age at diagnosis was independently associated with worse survival for all sites. In a subset analysis of 198 patients with OPC with available human papillomavirus (HPV) type 16 data, those with HPV-unrelated OPC had a significantly worse 3-year survival compared with those with HPV-related OPC (44.6% v 75.6%, respectively), corresponding to a 3.4 times higher mortality. CONCLUSION Late stage at diagnosis was the strongest predictor of lower HNSCC survival. Early cancer detection and reduction of harmful alcohol use are fundamental to decrease the high burden of HNSCC in South America. © 2020 by American Society of Clinical Oncology

Datos de la publicación

ISSN/ISSNe:: 2378-9506, 2378-9506
Tipo:: Article
Páginas:: 486-499
DOI:: 10.1200/GO.20.00014
Enlace a otro recurso:: www.scopus.com

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Keywords

Aged; Argentina; Brazil; Colombia; Head and Neck Neoplasms; Humans; Squamous Cell Carcinoma of Head and Neck; Uruguay; adult; aged; Article; cancer mortality; cancer staging; cancer survival; case control study; controlled study; female; follow up; head and neck squamous cell carcinoma; human; hypopharynx cancer; larynx cancer; lifestyle modification; major clinical study; male; medical record; mortality rate; mouth cancer; nonhuman; oropharynx cancer; overall survival; priority journal; South America; survival rate; Argentina; Brazil; Colombia; head and neck tumor; Uruguay