Portal de investigación
KRAS and MET in non-small-cell lung cancer: two of the new kids on the 'drivers' block
Fecha de publicación:
Autores organización
Autores
- Garcia-Robledo, JE
- Rosell, R
- Ruíz-Patiño, A
- Sotelo, C
- Arrieta, O
- Zatarain-Barrón, L
- Ordoñez, C
- Jaller, E
- Rojas, L
- Russo, A
- de Miguel-Pérez, D
- Rolfo, C
Grupos de investigación
Resumen
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized treatment based on the tumor's molecular genomics. This review presents a comprehensive review of the biology, new therapeutic interventions, and resistance patterns of two well-defined subgroups, tumors with KRAS and MET alterations. We also discuss the status of molecular testing practices for these two key oncogenic drivers, considering the progressive introduction of next-generation sequencing (NGS) and RNA sequencing in regular clinical practice.
Datos de la publicación
- ISSN/ISSNe:
- 1753-4658, 1753-4666
- Tipo:
- Review
- Páginas:
- -
- Enlace a otro recurso:
- www.scopus.com
Therapeutic Advances In Respiratory Disease SAGE PUBLICATIONS LTD
Citas Recibidas en Web of Science: 5
Citas Recibidas en Scopus: 11
Documentos
- No hay documentos
Filiaciones
Keywords
- biomarker; directed therapy; genomic profiling; KRAS; MET; non-small-cell lung cancer; resistance; targeted therapy; tumor genomics
Proyectos asociados
EFECTO DEL EXTRACTO DE Trametes versicolor SOBRE EL FENOTIPO Y LA FUNCIÓN DE CÉLULAS DENDRÍTICAS HUMANAS CONDICIONADAS CON MEDIOS DE CÉLULAS DE CARCINOMA ORAL
Investigador Principal: ANDRES FELIPE CARDONA MENDOZA
PCI-2019-10805 . 2020
Citar la publicación
Garcia JE,Rosell R,Ruíz A,Sotelo C,Arrieta O,Zatarain L,Ordoñez C,Jaller E,Rojas L,Russo A,de Miguel D,Rolfo C,Cardona AF. KRAS and MET in non-small-cell lung cancer: two of the new kids on the 'drivers' block. Ther Adv Respir Dis. 2022. 1617534666211066064. IF:4,300. (2).