Portal de investigación
Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
Fecha de publicación:
Fecha Ahead of Print:
Autores organización
Autores
- Denninghoff V
- Russo A
- de Miguel-Pérez D
- Malapelle U
- Benyounes A
- Gittens A
- Rolfo C
Grupos de investigación
Resumen
Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra-and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Datos de la publicación
- ISSN/ISSNe:
- 2072-6694, 2072-6694
- Tipo:
- Review
- Páginas:
- -
- Enlace a otro recurso:
- www.scopus.com
Cancers MDPI AG
Citas Recibidas en Web of Science: 9
Citas Recibidas en Scopus: 22
Documentos
- No hay documentos
Filiaciones
Keywords
- CD56 antigen; chromogranin A; cyclophosphamide; DNA topoisomerase inhibitor; doxorubicin; E1A associated p300 protein; ephrin receptor A7; fibroblast growth factor receptor 1; gyrase inhibitor; homeobox protein Nkx 2.1; KMT2D protein; lurbinectedin; mammalian target of rapamycin; methyltransferase; mixed lineage leukemia protein; Myc protein; neurogenic differentiation factor; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; Notch receptor; phosphatidylinositol 3 kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platinum complex; protein kinase B; protein p53; protein Ret; Slit2 protein; sonic hedgehog protein; synaptophysin; tarlatamab; transcription factor Yap1; tumor protein p73; unclassified drug; cancer genetics; cancer growth; cancer immunotherapy; cancer prognosis; cancer survival; carcinogenesis; cell cycle regulation; differentiation; enzyme activity; epigenetics; gene expression regulation; gene mutation; genetic analysis; hu
Proyectos asociados
Determinación de la huella transcipcional de mastocitos aislados de pulpa dental humana sana y con signos clínicos de inflamación
Investigador Principal: MARIA ROSA BUENAHORA TOBAR
PCI-2019-10765 . 2020
EFECTO DEL EXTRACTO DE Trametes versicolor SOBRE EL FENOTIPO Y LA FUNCIÓN DE CÉLULAS DENDRÍTICAS HUMANAS CONDICIONADAS CON MEDIOS DE CÉLULAS DE CARCINOMA ORAL
Investigador Principal: ANDRES FELIPE CARDONA MENDOZA
PCI-2019-10805 . 2020
Citar la publicación
Denninghoff V,Russo A,de Miguel D,Malapelle U,Benyounes A,Gittens A,Cardona AF,Rolfo C. Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective. Cancers (Basel). 2021. 13(7):1723. IF:6,575. (1).