Dengue-chikungunya coinfection outbreak in children from Cali, Colombia, in 2018-2019

Autores organización

• 

  Jaime Eduardo Castellanos Parra

  Autor

• Carolina Coronel Ruiz

  Autor

• 

  Eliana Patricia Calvo Tapiero

  Autor

• 

  Myriam Lucia Velandia Romero

  Autor

Autores

• Jaimes, N
• Rojas, JP
• Mejía, LF
• Villarreal, VH
• Maya, LE
• Claros, LM
• Orjuela, C
• Muñoz, MV

Grupos de investigación

• Grupo de Virología

  

  Investigador

  Jaime Eduardo Castellanos Parra

Resumen

Objective: To identify the arbovirus involved in febrile cases identified in a pediatric clinic in Cali, Valle del Cauca province, Colombia, and study the clinical characteristics. Methods: A descriptive, prospective study enrolled 345 febrile children for 12 months in a pediatric clinic. Serum samples and medical record registers documenting signs and symptoms were analyzed to detect DENV, CHIKV, and ZIKV by reverse transcription-polymerase chain reaction and serology methods. Diagnosis at the time of admission and discharge were compared based on laboratory test results. Results: All patients were diagnosed as severe dengue at admission. Molecular detection and serology tests identified 143 CHIKV-positive (41.4%), 20 DENV-positive (5.8%), and 123 DENV-CHIKV coinfection patients (35.7%). DENV or CHIKV serology test results of these double-infected patients yielded poor performance to confirm patient cases. ZIKV infection was detected in 5 patients (1.4%) as double or triple infections. Conclusion: A sustained CHIKV circulation and transmission was confirmed causing febrile illness in children and indicating that this virus spreads even during the regular DENV season, leading to double infections and altering clinical symptoms. Specific clinical tests are necessary to closely identify the arbovirus involved in causing infectious diseases that can help in better treatment and mosquito transmitted virus surveillance. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords

• Dengue fever; Chikungunya fever; RT-PCR; Serology; Arbovirus