Portal de investigación
Impact of detecting plasma EGFR mutations with ultrasensitive liquid biopsy in outcomes of NSCLC patients treated with first- or second-generation EGFR-TKIs
Autores organización
Autores
- Arrieta, O
- Hernandez-Martinez, JM
- Montes-Servín, E
- Heredia, D
- Molina-Romero, C
- Lara-Mejía, L
- Diaz-Garcia, D
- Bahena-Gonzalez, A
- Mendoza-Oliva, DL
Grupos de investigación
Resumen
BACKGROUND: Few trials have evaluated the utility of liquid biopsies to detect epidermal growth factor receptor mutations (EGFRm) at the time of response evaluation and its association with the clinical characteristics and outcomes of non-small-cell lung cancer (NSCLC) patients. OBJECTIVE: This study aimed to evaluate, in a real-world clinical setting, the prevalence of plasma EGFRm and its association with the clinical characteristics, response and survival outcomes of NSCLC patients under treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKIs). METHODS: This observational study enrolled advanced or metastatic NSCLC patients, with confirmed tumor EGFRm, receiving treatment with first- or second-generation EGFR-TKIs. Blood samples for the detection of plasma EGFRm were collected at the time of response evaluation and processed using the Target Selector (TM) assay. The main outcomes were the detection rate of plasma EGFRm, median Progression-Free Survival (PFS) and Overall Survival (OS) according to plasma EGFR mutational status. RESULTS: Of 84 patients, 50 (59.5%) had an EGFRm detected in plasma. After a median follow-up of 21.1 months, 63 patients (75%) had disease progression. The detection rate of plasma EGFRm was significantly higher in patients with disease progression than in patients with partial response or stable disease (68.3% versus 33.3%; P < 0.01). PFS and OS were significantly longer in patients without plasma EGFRm than among patients with plasma EGFRm (14.3 months [95% CI, 9.25-19.39] vs 11.0 months [95% CI, 8.61-13.46]; P = 0.034) and (67.8 months [95% CI, 39.80-95.94] vs 32.0 months [95% CI, 17.12-46.93]; P = 0.006), respectively. A positive finding in LB was associated with the presence of >= 3 more metastatic sites (P = 0.028), elevated serum carcinoembryonic (CEA) at disease progression (P = 0.015), and an increase in CEA with respect to baseline levels (P = 0.038). CONCLUSIONS: In NSCLC patients receiving EGFR-TKIs, the detection of plasma EGFRm at the time of tumor response evaluation is associated with poor clinical outcomes.
Datos de la publicación
- ISSN/ISSNe:
- 1574-0153, 1875-8592
- Tipo:
- Article
- Páginas:
- 123-135
- DOI:
- 10.3233/CBM-203164
- Enlace a otro recurso:
- www.scopus.com
Cancer Biomarkers IOS PRESS
Citas Recibidas en Web of Science: 2
Citas Recibidas en Scopus: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- ctDNA; EGFR-TKI resistance; lung adenocarcinoma; clinical progression; liquid biopsy
Proyectos asociados
Determinación de la huella transcipcional de mastocitos aislados de pulpa dental humana sana y con signos clínicos de inflamación
Investigador Principal: MARIA ROSA BUENAHORA TOBAR
PCI-2019-10765 . 2020
EFECTO DEL EXTRACTO DE Trametes versicolor SOBRE EL FENOTIPO Y LA FUNCIÓN DE CÉLULAS DENDRÍTICAS HUMANAS CONDICIONADAS CON MEDIOS DE CÉLULAS DE CARCINOMA ORAL
Investigador Principal: ANDRES FELIPE CARDONA MENDOZA
PCI-2019-10805 . 2020
Citar la publicación
Arrieta O,Hernandez JM,Montes E,Heredia D,Cardona AF,Molina C,Lara L,Diaz D,Bahena A,Mendoza DL. Impact of detecting plasma EGFR mutations with ultrasensitive liquid biopsy in outcomes of NSCLC patients treated with first- or second-generation EGFR-TKIs. Cancer Biomark. 2021. 32. (2):p. 123-135. IF:3,828. (3).