Portal de investigación
When Tissue is an Issue the Liquid Biopsy is Nonissue: A Review
Fecha de publicación:
Fecha Ahead of Print:
Autores organización
Autores
- Rodríguez, J
- Avila, J
- Rolfo, C
- Ruíz-Patiño, A
- Russo, A
- Ricaurte, L
- Ordóñez-Reyes, C
- Arrieta, O
- Zatarain-Barrón, ZL
- Recondo, G
Grupos de investigación
Resumen
Precision medicine has impacted the field of medical oncology by introducing personalized therapies, improving all measurable outcomes. This field, in turn, has expanded to obtaining and analyzing a vast and ever-increasing amount of genomic information. One technique currently applied is the liquid biopsy, which consists of detecting and isolating DNA and exosomes in cancer patients. Newly developed techniques have made it possible to use the liquid biopsy in a wide range of settings. However, challenges regarding the validation of its clinical utility exist because of a lack of standardization across different techniques and tumor types, confounder genomic information, lack of appropriate clinical trial designs, and a non-measured, and therefore not estimated, economic impact on population health. Nowadays, liquid biopsy is not routinely used, but ongoing research is increasing its popularity, and a new era in oncology is developing. Therefore, it is essential to have an in-depth understanding of the liquid biopsy technique. In this review, we summarize the leading techniques and liquid biopsy applications in cancer.
Datos de la publicación
- ISSN/ISSNe:
- 2366-1070, 2366-1089
- Tipo:
- Review
- Páginas:
- 89-110
Oncology And Therapy SPRINGER
Citas Recibidas en Web of Science: 28
Documentos
- No hay documentos
Filiaciones
Keywords
- Cell-free DNA; Circulating tumor cells; Diagnosis; Liquid biopsy; Screening
Proyectos asociados
Determinación de la huella transcipcional de mastocitos aislados de pulpa dental humana sana y con signos clínicos de inflamación
Investigador Principal: MARIA ROSA BUENAHORA TOBAR
PCI-2019-10765 . 2020
EFECTO DEL EXTRACTO DE Trametes versicolor SOBRE EL FENOTIPO Y LA FUNCIÓN DE CÉLULAS DENDRÍTICAS HUMANAS CONDICIONADAS CON MEDIOS DE CÉLULAS DE CARCINOMA ORAL
Investigador Principal: ANDRES FELIPE CARDONA MENDOZA
PCI-2019-10805 . 2020
Citar la publicación
Rodríguez J,Avila J,Rolfo C,Ruíz A,Russo A,Ricaurte L,Ordóñez C,Arrieta O,Zatarain ZL,Recondo G,Cardona AF. When Tissue is an Issue the Liquid Biopsy is Nonissue: A Review. Oncol Ther. 2021. 9(1):p. 89-110.