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Characteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP-LATimus)

Fecha de publicación: Fecha Ahead of Print:

Autores organización

  • Andres Felipe Cardona Mendoza

    Autor

  • Luis Leonardo Rojas Beltran

    Autor

Autores

  • Martín, C
  • Enrico, D
  • Mas, L
  • Patane, AK
  • Arrieta, O
  • Soria, T
  • Ruiz-Patiño, A
  • Ruiz, R
  • Rioja, P
  • Lozano, S
  • Zatarain-Barrón, ZL
  • Barrón, F
  • Puparelli, C
  • Tsou, FC
  • Corassa, MP
  • Freitas, HC
  • de Lima, VCC
  • Ordóñez-Reyes, C
  • Corrales, L
  • Sotelo, C
  • Rodríguez, J
  • Ricaurte, L
  • Avila, J
  • Archila, P
  • Rosell, R
  • Cuello, M
  • Remon, J
  • CLICaP

Grupos de investigación

Resumen

Background Thymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America. Methods This was a retrospective multicenter cohort study including patients with histologically proven thymomas diagnosed between 1997 and 2018. Demographics, clinicopathological characteristics and therapeutic outcomes were collected locally and analyzed in a centralized manner. Results A total of 135 patients were included. Median age at diagnosis was 53 years old (19-84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG performance score ranging from 0-1. A total of 47 patients (34.8%) had metastatic disease at diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgery was performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and 47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival (OS) at five-years was 73.4%, 63.8% and 51%, at stages I-II, III-IVA and IVB, respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase (LDH) (<= 373 IU/L) at baseline and myasthenia gravis concurrence showed significantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, high LDH levels (HR 2.8 [95% confidence interval [CI]: 1.1-7.8]; p = 0.036) at baseline and not performing a surgical resection (HR 4.1 [95% CI: 1.3-12.7]; p = 0.016) were significantly associated with increased risk of death. Conclusions Our data provides the largest insight into the clinical characteristics and outcomes of patients with thymomas in Latin America. Survival in patients with thymomas continues to be very favorable, especially when subjected to adequate local control.

© 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

Datos de la publicación

ISSN/ISSNe:
1759-7706, 1759-7714

Thoracic Cancer  John Wiley and Sons Inc

Tipo:
Article
Páginas:
1328-1335

Citas Recibidas en Web of Science: 4

Citas Recibidas en Scopus: 2

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Keywords

  • cohort studies; Latin America; medical oncology; thymoma

Campos de estudio

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PCI-2019-10765 . 2020

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Investigador Principal: ANDRES FELIPE CARDONA MENDOZA

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