Portal de investigación
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer
Autores organización
Autores
- Malapelle, U
- Pisapia, P
- Addeo, A
- Arrieta, O
- Bellosillo, B
- Cristofanilli, M
- De Miguel-Perez, D
- Denninghoff, V
- Durán, I
- Jantus-Lewintre, E
- Nuzzo, PV
- O'Byrne, K
- Pauwels, P
- Pickering, EM
- Raez, LE
- Russo, A
- Serrano, MJ
- Gandara, DR
- Troncone, G
- Rolfo, C
- Int Soc Liquid Biopsy
Grupos de investigación
Resumen
Introduction In the current era of personalized medicine, liquid biopsy has acquired a relevant importance in patient management of advanced stage non-small cell lung cancer (NSCLC). As a matter of fact, liquid biopsy may supplant the problem of inadequate tissue for molecular testing. The term 'liquid biopsy' refers to a number of different biological fluids, but is most clearly associated with plasma-related platforms. It must be taken into account that pre-analytical processing and the selection of the appropriate technology according to the clinical context may condition the results obtained. In addition, novel clinical applications beyond the evaluation of the molecular status of predictive biomarkers are currently under investigation. Areas covered This review summarizes the available evidence on pre-analytical issues and different clinical applications of liquid biopsies in NSCLC patients. Expert opinion Liquid biopsy should be considered not only as a valid alternative but as complementary to tissue-based molecular approaches. Careful attention should be paid to the optimization and standardization of all phases of liquid biopsy samples management in order to determine a significant improvement in either sensitivity or specificity, while significant reducing the number of 'false negative' or 'false positive' molecular results.
Datos de la publicación
- ISSN/ISSNe:
- 1473-7159, 1744-8352
- Tipo:
- Review
- Páginas:
- 1165-1178
Expert Review Of Molecular Diagnostics TAYLOR & FRANCIS AS
Citas Recibidas en Web of Science: 12
Citas Recibidas en Scopus: 25
Documentos
- No hay documentos
Filiaciones
Keywords
- Liquid biopsy; NSCLC; ctDNA; CTC; biomarkers
Proyectos asociados
Determinación de la huella transcipcional de mastocitos aislados de pulpa dental humana sana y con signos clínicos de inflamación
Investigador Principal: MARIA ROSA BUENAHORA TOBAR
PCI-2019-10765 . 2020
EFECTO DEL EXTRACTO DE Trametes versicolor SOBRE EL FENOTIPO Y LA FUNCIÓN DE CÉLULAS DENDRÍTICAS HUMANAS CONDICIONADAS CON MEDIOS DE CÉLULAS DE CARCINOMA ORAL
Investigador Principal: ANDRES FELIPE CARDONA MENDOZA
PCI-2019-10805 . 2020
Citar la publicación
Malapelle U,Pisapia P,Addeo A,Arrieta O,Bellosillo B,Cardona AF,Cristofanilli M,De Miguel D,Denninghoff V,Durán I,Jantus E,Nuzzo PV,O'Byrne K,Pauwels P,Pickering EM,Raez LE,Russo A,Serrano MJ,Gandara DR,Troncone G,Rolfo C,Int Soc Liquid B. Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer. Expert Rev Mol Diagn. 2021. 21(11):p. 1165-1178. IF:5,670. (1).