Portal de investigación
Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome
Fecha de publicación:
Autores organización
Autores
- Lynch, RM
- Mantus, G
- Encinales, L
- Pacheco, N
- Li, GZ
- Mendoza, AR
- Peng, J
- Rengifo-Pardo, M
- Cruz, MM
- Harris, E
- Bethony, JM
- Simon, GL
- Chang, AY
Grupos de investigación
Resumen
The role of neutralizing antibodies in Zika-induced Guillain-Barre syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
Datos de la publicación
- ISSN/ISSNe:
- 0022-1899, 1537-6613
- Tipo:
- Article
- Páginas:
- 26-30
- PubMed:
- 30113672
Journal Of Infectious Diseases Oxford University Press
Citas Recibidas en Web of Science: 15
Citas Recibidas en Scopus: 25
Documentos
- No hay documentos
Filiaciones
Keywords
- Guillain-Barre syndrome; neutralizing antibody; flavivirus; Zika; dengue
Proyectos asociados
Prevalencia y Modelación de la infección por Virus de la Hepatitis C en Colombia
Investigador Principal: ALEXANDRA PORRAS RAMIREZ
2017