Portal de investigación
Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome
Fecha de publicación:
Autores organización
Autores
- Lynch, RM
- Mantus, G
- Encinales, L
- Pacheco, N
- Li, GZ
- Mendoza, AR
- Peng, J
- Rengifo-Pardo, M
- Cruz, MM
- Harris, E
- Bethony, JM
- Simon, GL
- Chang, AY
Grupos de investigación
Resumen
The role of neutralizing antibodies in Zika-induced Guillain-Barre syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
Datos de la publicación
- ISSN/ISSNe:
- 0022-1899, 1537-6613
- Tipo:
- Article
- Páginas:
- 26-30
Journal Of Infectious Diseases Oxford University Press
Citas Recibidas en Web of Science: 15
Citas Recibidas en Scopus: 24
Documentos
- No hay documentos
Filiaciones
Keywords
- Guillain-Barre syndrome; neutralizing antibody; flavivirus; Zika; dengue
Proyectos asociados
Prevalencia y Modelación de la infección por Virus de la Hepatitis C en Colombia
Investigador Principal: ALEXANDRA PORRAS RAMIREZ
2017
Citar la publicación
Lynch RM,Mantus G,Encinales L,Pacheco N,Li GZ,Porras A,Mendoza AR,Peng J,Rengifo M,Cruz MM,Harris E,Bethony JM,Simon GL,Chang AY. Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome. J Infect Dis. 2019. 219. (1):p. 26-30. IF:5,022. (1).