Usefulness of immature platelet fraction measurement in predicting hematologic recovery in patients with acute leukemias undergoing high-intensity chemotherapy and stem cell transplantation

Autores organización

• Alexandra Porras Ramirez

  Autor

• Franklin Alejandro Rico Mendoza

  Autor

Autores

• López A.B.S.
• Cordero R.H.M.
• Luque G.P.D.
• Calle R.M.J.
• Hawkins M.M.L.
• Martínez L.M.S.
• Aljurf M.D.
• Kharfan-Dabaja M.A.

Unidades de investigación

• Esclerosis múltiple y otros trastornos neurológicos

  Investigador

  Jaime Toro Gomez

• Grupo de Investigación Medicina Materno Fetal y Ginecología - El Bosque MMFG-EB

  Investigador

  Ximena Carolina Romero Infante

• Medicina Comunitaria y Salud Colectiva

  Investigador principal

  Alexandra Porras Ramirez

• Saneamiento Ecológico, Salud y Medio Ambiente

  

  Investigador

  Diana Marcela Sarmiento Senior

Resumen

BACKGROUND AND OBJECTIVES: The immature platelet fraction (IPF) count is a parameter that quantifies young and reticulated platelets in peripheral blood, which reflects platelet production in the bone marrow. It has been used as a predictive model for bone marrow recovery in patients with acute leukemia after high-intensity chemotherapy and/or stem cell transplantation. This study aimed to evaluate IPF as a predictor of hematologic recovery in these patients. MATERIALS AND METHODS: A retrospective analysis of patients with acute leukemias after high-intensity chemotherapy or undergoing stem cell transplantation, treated at the Instituto Nacional de Cancerología (INC) (Bogotá, Colombia) between October 2020 and March 2021.The variables studied included age, sex, type of leukemia, type of treatment, type of chemotherapy, treatment duration, peripheral blood platelet count, percentage of IPF (IPF%), and peripheral blood neutrophil count. Univariate and multivariate analyses were carried out to evaluate the relationship between the IPF behavior and hematologic recovery. Statistical analysis was performed using the R package version 4.2.0® (free license). RESULTS: Between October 2020 and March 2021, 32 patients were analyzed, with a median age of 26 years; the male population was 59.4%. Acute lymphoid leukemia was the most frequent type in 62.5%; 43.7% of patients received chemotherapy, while the others underwent allogeneic stem cell transplantation. Hematologic recovery occurred between days 15 and 30. Spearman's correlation was 0.27 with a p=0.13 for recovery day and IPF% (weak correlation). CONCLUSION: There is limited information regarding the usefulness of IPF% in hematology. The IPF% was not found to be a predictor of hematologic recovery in patients with acute leukemia after chemotherapy and/or allogeneic stem cell transplantation. The lack of correlation does not allow for assuming a reliable cut-off point. Further studies with a larger sample size are needed. Copyright © 2025 Hematology/Oncology and Stem Cell Therapy.

Keywords

• Adolescent; Adult; Blood Platelets; Child; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Middle Aged; Platelet Count; Retrospective Studies; Young Adult; acute myeloid leukemia; adolescent; adult; blood; child; female; hematopoietic stem cell transplantation; human; leukemia; male; middle aged; platelet count; retrospective study; therapy; thrombocyte; young adult