Second-trimester Ultrasound and Neuropathologic Findings in Congenital Zika Virus Infection

Autores organización

• Alexandra Porras Ramirez

  Autor

Autores

• Ho C.-Y.
• Castillo N.
• Encinales L.
• Mendoza A.R.
• Lynch R.
• Nemirovsky A.
• Mantus G.
• Debiasi R.L.
• Bethony J.M.
• Simon G.L.
• Chang A.Y.

Unidades de investigación

• Esclerosis múltiple y otros trastornos neurológicos

  Investigador

  Jaime Toro Gomez

• Grupo de Investigación Medicina Materno Fetal y Ginecología - El Bosque MMFG-EB

  Investigador

  Ximena Carolina Romero Infante

• Medicina Comunitaria y Salud Colectiva

  Investigador principal

  Alexandra Porras Ramirez

• Saneamiento Ecológico, Salud y Medio Ambiente

  

  Investigador

  Diana Marcela Sarmiento Senior

Resumen

Zika virus is a mosquito-borne virus that causes congenital Zika syndrome, characterized by microcephaly and other fetal brain anomalies. This case report presents a case of Zika virus-related fetal brain anomalies including pathologic evidence of cerebral neuronal apoptosis and macrophage infiltrates and intracerebral calcification, ventriculomegaly and corpus callosum dysgenesis detected by ultrasound at 18 weeks of pregnancy. © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

• Adult; Brain; Female; Humans; Nervous System Diseases; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Ultrasonography, Prenatal; Zika Virus; Zika Virus Infection; immunoglobulin G antibody; immunoglobulin M antibody; virus antibody; virus envelope protein; virus RNA; adult; amnion fluid; antibody titer; arthralgia; Article; brain calcification; brain ventricle dilatation; case report; cerebellum hypoplasia; cerebellum vermis; clinical article; congenital infection; conjunctivitis; corpus callosum agenesis; EC50; female; fetus; fetus brain; fetus echography; fever; gestational age; human; human tissue; lateral brain ventricle; macrophage; microcephaly; neuroapoptosis; neuropathology; peripheral edema; priority journal; real time polymerase chain reaction; second trimester pregnancy; spinal cord ventral horn; subventricular zone; tissue section; young adult; Zika fever; brain; diagnostic imaging; fetus echography; neurologic disease; pathology; pregnancy; pr