Rapid Diagnostic Test Value and Implementation in Antimicrobial Stewardship Across Low-to-Middle and High-Income Countries: A Mixed-Methods Review

Fecha de publicación: 01/01/2023 Fecha Ahead of Print: 01/06/2023

Autores organización

Maria Virginia Villegas Botero

Autor

Autores

Moore LSP
Wenzler E
Rawson TM
Oladele RO
Doi Y
Apisarnthanarak A

Grupos de investigación

Grupo de Investigación en Resistencia Antimicrobiana y Epidemiología Hospitalaria RAEH

Investigador

Maria Virginia Villegas Botero

Resumen

Despite technological advancements in infectious disease rapid diagnostic tests (RDTs) and use to direct therapy at the per-patient level, RDT utilisation in antimicrobial stewardship programmes (ASPs) is variable across low-to-middle income and high-income countries. Key insights from a panel of seven infectious disease experts from Colombia, Japan, Nigeria, Thailand, the UK, and the USA, combined with evidence from a literature review, were used to assess the value of RDTs in ASPs. From this, a value framework is proposed which aims to define the benefits of RDT use in ASPs, separate from per-patient benefits. Expert insights highlight that, to realise the value of RDTs within ASPs, effective implementation is key; actionable advice for choosing an RDT is proposed. Experts advocate the inclusion of RDTs in the World Health Organization Model List of essential in vitro diagnostics and in iterative development of national action plans. © 2023, The Author(s).

Datos de la publicación

ISSN/ISSNe:: 2193-8229, 2193-6382
Tipo:: Note
Páginas:: 1445-1463
DOI:: 10.1007/s40121-023-00815-z
Enlace a otro recurso:: www.scopus.com

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Métricas

Filiaciones

Moore LSP:: Clinical Infection Department, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, United Kingdom

Imperial College Healthcare NHS Trust, North West London Pathology, London, United Kingdom

NIHR Health Protection Research Unit in Healthcare Associated Infections & Antimicrobial Resistance, Imperial College London, London, United Kingdom
Villegas MV:: Universidad. Grupo de Resistencia Antimicrobiana y Epidemiología Hospitalaria, Universidad El Bosque, Bogotá, Colombia

Universidad. Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia
Wenzler E:: College of Pharmacy, University of Illinois at Chicago, Chicago, IL, United States
Rawson TM:: NIHR Health Protection Research Unit in Healthcare Associated Infections & Antimicrobial Resistance, Imperial College London, London, United Kingdom

Centre for Antimicrobial Optimisation, Imperial College London, London, United Kingdom
Oladele RO:: Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria
Doi Y:: Department of Infectious Diseases, Fujita Health University School of Medicine, Aichi, Toyoake, Japan

Department of Microbiology, Fujita Health University School of Medicine, Aichi, Toyoake, Japan

Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
Apisarnthanarak A:: Research Group in Infectious Diseases Epidemiology and Prevention, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand

Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand

Keywords

antibiotic resistance; antigen test; antimicrobial stewardship; antimicrobial stewardship program; behavior; biochemical chromogenic assay; Colombia; cost effectiveness analysis; diagnostic procedure; education; general pathological parameters; high income country; human; interpersonal communication; length of stay; low income country; medical expert; microorganism detection; middle income country; mortality; Note; nuclear magnetic resonance imaging; patient care pathway; patient care; point of care testing; polymerase chain reaction; rapid diagnostic test value; semi structured interview; World Health Organization