Porphyromonas gingivalis and IgG1 and IgG2 subclass antibodies in patients with juvenile idiopathic arthritis

Autores organización

• Maria Consuelo Romero Sanchez

  Autor

• 

  Diana Marcela Castillo Perdomo

  Autor

• 

  Juliette De Avila Quiroga

  Autor

• 

  Gloria Ines Lafaurie Villamil

  Autor

Autores

• Malagón C.
• Vargas C.
• Torres M.F.
• Moreno L.C.
• Rodríguez C.
• Mosquera Á.C.

Unidades de investigación

• Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

  Investigador

  Maria Consuelo Romero Sanchez

• Unidad de Investigación Básica Oral UIBO

  

  Investigador

  Gloria Ines Lafaurie Villamil

Resumen

Purpose: The purpose of this study was to evaluate the periodontal status and the presence and concentration of Porphyromonas gingivalis (P. gingivalis) and immunoglobulin G (IgG) subclass against P. gingivalis in juvenile idiopathic arthritis (JIA) and its association with rheumatic clinical activity parameters. Methods: Rheumatologic conditions and periodontal status were clinically assessed in 51 patients with JIA. P. gingivalis, IgG1 and IgG2, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs), and human leukocyte antigen B27 were also evaluated. Results: Periodontitis was observed in 21.5 percent of the patients, 23.5 percent of whom were positive for P. gingivalis, which was associated with enthesitis-related arthritis (P<0.035). IgG1 against P gingivalis was associated with RF autoantibodies (P=0.05), and all patients positive for ACPAs had higher anti-P gingivalis IgG1 levels. A significant correlation was found between the presence of limited joint mobility and the plaque index in polyarticular JIA (r=0.55, P=0.028). Conclusions: An association between IgG and rheumatic disease activity markers in JIA was evident. It is important to investigate the familiar periodontal status and clinical course in JIA, especially in enthesitis-related arthritis.

Keywords

• Adolescent; Arthritis, Juvenile; Bacteroidaceae Infections; Female; Humans; Immunoglobulin G; Male; Periodontitis; Porphyromonas gingivalis; Severity of Illness Index; immunoglobulin G; adolescent; Bacteroidaceae infection; blood; complication; female; human; immunology; juvenile rheumatoid arthritis; male; microbiology; periodontitis; Porphyromonas gingivalis; severity of illness index