Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?

Autores organización

• Wilson Armando Bautista Molano

  Autor

• 

  Gloria Ines Lafaurie Villamil

  Autor

• Leidy Lorena Chila Moreno

  Autor

• Maria Consuelo Romero Sanchez

  Autor

Autores

• Unriza-Puin S.
• Valle-Oñate R.
• Chalem P.
• Bello-Gualtero J.M.

Unidades de investigación

• Grupo de Inmunología celular y molecular Universidad El Bosque (InmuBo)

  Investigador

  Maria Consuelo Romero Sanchez

• Unidad de Investigación Básica Oral UIBO

  

  Investigador

  Gloria Ines Lafaurie Villamil

Resumen

The aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P. gingivalis antibodies was evaluated. Groupwise comparisons were analysed using the McNemar and Wilcoxon tests. A conditional logistic regression analysis was performed to establish the associations between BMI, ACPAs and periodontitis in both groups. In the FDR group, 70% of the subjects were female, with a mean age of 37.3 ± 13 years. Obesity was observed in 17 and 7% of the FDRs and controls, respectively. ACPAs were found in 7% of the FDRs vs. 2.5% of the controls. Periodontitis was diagnosed in 79 and 56% of the FDRs and controls, respectively. Among the FDRs, 15% had severe periodontitis. There were associations in the FDR group related to the presence of obesity (OR 2.93, 95% CI 1.03–8.28), ACPAs (OR 2.45, 95% CI 0.7–8.32) and periodontitis (OR 3.70 95% CI 1.89–7.29). Regarding anti-P. gingivalis antibodies and smoking history, no differences were found between the groups. Obesity, ACPAs and periodontitis (diagnosis and severity) can be considered as relevant conditions associated with the development of RA in FDRs. © 2016, International League of Associations for Rheumatology (ILAR).

Keywords

• Adolescent; Adult; Aged; Antibodies, Bacterial; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Body Mass Index; Case-Control Studies; Colombia; Cross-Sectional Studies; Family Health; Female; Humans; Immunoglobulin G; Logistic Models; Male; Middle Aged; Obesity; Periodontitis; Porphyromonas gingivalis; Risk Assessment; Risk Factors; Young Adult; anticitrullinated protein antibody; bacterium antibody; immunoglobulin G1; immunoglobulin G2; protein antibody; unclassified drug; autoantibody; immunoglobulin G; adult; aged; Article; body mass; controlled study; cross-sectional study; disease severity; female; first-degree relative; human; major clinical study; male; McNemar test; obesity; periodontitis; Porphyromonas gingivalis; priority journal; rank sum test; rheumatoid arthritis; smoking; adolescent; antibody specificity; blood; case control study; Colombia; complication; family health; middle aged; obesity; periodontitis; rheumatoid arthritis; risk assessment; risk factor;